Best rated probiotics supplements

Probiotics can work wonders for our skin, gut, immunity, and more. Learn how to identify one with the potency needed to make an impact.

Humans have used probiotics for over 10,000 years.1 Likely discovered by accident, (Although there's no specific evidence to support humans' first usage of probiotics, most researchers agree that they were likely created purely by accident when our ancestors traversed high-temperature deserts carrying milk in bags made from sheep stomachs. The naturally-occurring probiotics in these bags changed the flavor of the milk inside, just like yogurt and cheese today. These changes conferred noticeable health benefits and extended preservation, making them a staple for civilizations worldwide since ancient times.) our understanding of their extensive benefits has grown exponentially in modern times.

The vast majority of our immune systems — 70% — resides in our gut. Unfortunately, the delicate balance of our gut microbiome, (The human body contains more bacterial cells than human cells. In fact, the ratio is 10-1. Our microbiome is the collection of good and bad bacteria in our gut. Keeping a healthy balance of good bacteria can have huge benefits not only for our digestion, but our brain, skin, immune system, and a host of other functions.) can be thrown off by simple everyday things beyond our control — stress, pollution, lack of sleep, or food.

Probiotics hold the key to balancing the gut microbiome and strengthening our immune system. They protect our bodies from dangerous pathogens, promote energy, enhance mood, and enrich our health in numerous ways.

Not all probiotics are equal, so Smarter Reviews delved into the research for this popular category. We'll break down how to identify a potent supplement and show you our Top 5 Probiotic Supplements on the market today.

A Brief History of Probiotics

Records and artifacts show that probiotics and fermented foods have been used since ancient times.

7,000 B.C. — Ancient Egyptians accidentally created fermented milk products. With noticeable health and preservation qualities, these cheeses, yogurts, and butters became widely used.3

1300 B.C. — Fermented milk offered to God in The Bible — “Abraham offered to God, showed in an oak wood, fermented milk” (The Bible, Genesis 18, 1–8).3

1908 AD — Nobel-prize winner and The Father of Cellular Immunology — Ilya Mechnikoff theorizes that the friendly bacteria in yogurt could improve physical and mental health.4

1935 — First commercial probiotic, Yakult, a fermented milk product, released in Japan.5

2001 — The World Health Organization establishes a definition for probiotics, "live microorganisms, which when administered in adequate amounts, confer a health benefit on the host." 6

2019 —Global probiotics supplement market tops $40 billion annually.

Despite their popularity over the centuries, research into probiotics has taken a dramatic leap within the last 40 years. We now know that there are hundreds of different probiotic strains, and they all perform different functions within our bodies. Some strains enhance our digestive systems, minimizing symptoms like diarrhea or constipation. Some promote clear, glowing skin or healthy hair. Others enhance our mood, energy, or mental clarity. And still others enhance our immunity.

When it comes to choosing a high-quality probiotic supplement, strain selection is just one factor to consider. Potency, viability, CFU, and clinically studied strains all play a significant role in determining health benefit.

What To Avoid When Choosing a Probiotic

Limited Strains

Many supplements only contain one or only a few different probiotic strains. Probiotics strains all serve different purposes within the body, so a product with just a few strains limits the overall effectiveness our health. Probiotics supplements offering a more comprehensive approach provide a more substantial and longer term impact on our health and immunity. Look for a supplement with at least 9 individual strains.

Probiotics Without Clinical Studies

When you look at the label of a high-quality probiotic supplement, each strain will list a series of letters and numbers following the strain name, such as La-14. This indicates the DNA sequence of a particular strain has been identified. These series provide a useful tool for consumers to evaluate whether clinical studies exist behind a particular strain.

Many probiotic formulations do not list their specific substrains. This suggests the brand may be using generic (and cheaper) strains that have not been clinically studied. For optimal results, select a probiotic supplement with substrains listed.

Refrigerated Probiotics

Refrigerated products can be damaged during shipping. They also may lack the hardiness to survive the hot, acidic conditions in our gut. We suggest choosing a probiotic that is well-formulated to withstand room temperature and does not require being refrigerated during periods of non-use.

4 Secrets of A Good Probiotic

High CFU Count

Since our microbiome is composed of about 100 trillion good and bad bacteria, a high number of Colony Forming Units (CFUs) will have greater impact on the growth of beneficial bacteria within our gut.23 It's essential to choose a probiotic which specifies CFU versus "active cultures" or "live cultures." Look for a formula with a minimum of 40 billion CFU.


The latest research shows that fiber-based prebiotics (such as NutraFlora Fiber) feed the probiotics, helping them to populate and flourish in our gut.24 Choose probiotics supplements containing prebiotics to significantly increase the overall effectiveness of the probiotic.

Clinically Studied Strains

There are hundreds of different probiotics strains, but many have never been proven effective. The best way to identify the potency of a particular strain is to look at the clinical studies backing it up. To find out if a particular strain has clinical backing, search the strain name on the internet. Look for strains proven effective by clinical studies.

Formulated By A Doctor

It takes specific expertise to form an effective probiotic formulation. More is not necessarily better. The exact combination of strain type, potency, quantity, and prebiotics determines the product's quality. Look for real doctors specializing in gut health backing the product.

Some lucky people can eat anything without getting an upset tummy. But for others, life – and eating – aren’t quite as simple.

Lots of people struggle with bacterial imbalances in their digestive systems. These imbalances cause all sorts of health issues such as weight gain, digestive problems, poor immune function, and many other disruptive symptoms.

Taking the best-rated probiotics supplements can help you restore the balance of “good” and “bad” bacteria in your digestive system, so you can eat and live more comfortably and achieve your health goals.


There are quite a few different probiotic manufacturers on the market. In this guide, we’re going to cover five of the best probiotic products that consumers buy, love, and believe in. When you purchase from a trusted brand, you increase your chances of finding a good product that offers you the most benefits and works with your unique digestive system.

Let’s take a look!

1. Physician’s Choice 60 Billion Probiotic


  • Weight – 2.4 ounces
  • Size – 4.5 x 2.4 x 2.4 inches
  • Qty pack – 30
  • Sensitivities – Gluten-free, shellfish-free, soy-free, dairy-free, egg-free, nut-free, vegan
  • Item form – Capsules
  • CFUs – 60 billion
  • Strains – 10
  • Dosage – 1 capsule per day (1 month supply)
  • Function – Boosts digestive health, immune support, promotes regularity, boosts nutrient absorption, reduces bloating and gas
  • Bottle includes 1 months’ supply
  • Perfect for people with gluten, shellfish, soy, and other allergies
  • 60 billion CFUs in one capsule
  • Boosts immune health
  • 10 strains per capsule
  • Promotes regularity
  • Boosts nutrient absorption
  • Reduces bloating and gas
  • Boosts digestive system
  • #1 best seller
  • It can take some time before you see results


This probiotic fiber blend is ideal for those who struggle with regularity, nutrient absorption, bloating, and gas. It also helps boost a healthy digestive system and can improve your immune function.

These probiotics by Physician’s Choice will supply you with 60 billion CFUs (colony-forming units) per capsule, as well as 10 strains of bacteria that play key roles in gut health. The product is also safe for those with food sensitivities and allergies, as the product is gluten, shellfish, soy, dairy, egg, and nut-free.

The product is very easy to consume and comes in the form of a simple capsule that you can easily swallow. Since one bottle contains 30 capsules and you only need to take one per day, one bottle of probiotics will be enough to last you a whole month.


2. Now Probiotic-10: 25 Billion with 10 Probiotic Strains


  • Weight – 1.76 ounces
  • Size – 1.94 x 1.94 x 4.13 inches
  • Qty pack – 30, 50, or 100
  • Item form – Capsules
  • Sensitivities – Soy-free, gluten-free, dairy-free, nut-free, vegan
  • CFU’s – 25 billion
  • Strains – 10
  • Dosage – 1-2 capsules per day
  • Function – Boosts immune system, assists digestive function
  • Comes in 30, 50, or 100-capsule bottles
  • Perfect for those with soy, gluten, dairy, nut, and other allergies
  • Offers 25 billion CFUs per capsule
  • Boosts immune health
  • 10 strains per capsule
  • Promotes regularity
  • Boosts your immune system
  • Assists your digestive function
  • An Amazon’s Choice product
  • Does not contain as many CFUs as other products
  • You might need to consume 2 capsules per day
  • Should be taken on an empty stomach


This probiotic by Now is ideal for those who don’t have severe tummy or gut issues, but still want to boost their immune system and promote a healthier digestive tract.

This supplement offers you 25 billion CFUs and 10 probiotic strains with every capsule. The capsules are very easy to swallow and you only need 1-2 per day to see results.

You can get this probiotic in packs of 30, 50, or 100. Larger adults should consider buying a bigger pack, because more than one capsule per day will likely be needed for effective results.

This is another ideal product for vegans or those with soy, gluten, dairy, and nut sensitivities because it’s free from all of those potential allergens. 


3. Naturelo 50 Billion CFU Probiotic Supplement


  • Weight – 2.4 ounces
  • Size – 1.5 x 2.2 x 4.4 inches
  • Qty pack – 30 or 60
  • Sensitivities – Soy-free, gluten-free, dairy-free, sugar-free, egg-free, nut-free, preservative-free, vegan
  • CFUs – 50 billion
  • Strains – 11
  • Dosage – 1 capsule per day
  • Function – Supports regularity and colon health, promotes gut lining health, reduces bloating and gas, improves nutrient consumption, assists immune health, assists weight loss, assists colon cleansing, assists digestion 
  • Large 60-capsule bottle lasts 2 months
  • Perfect for those with food and additive allergies
  • Offers 50 billion CFUs per capsule
  • 11 strains per capsule
  • Supports regularity
  • Reduces bloating and gas
  • Promotes colon health and immune system function
  • Increases nutrient consumption
  • Cleanses the colon
  • Aids digestion
  • May not be effective for heartburn symptoms


These probiotics by Naturelo are great for those who struggle with irregularity, bloating, gas, poor nutrient consumption, weight problems, and colon issues. They will also boost your overall immune system and improve the functioning of your digestive system.

This probiotic supplement offers you 50 billion CFUs and 11 strains per capsule. The bottle includes 60 capsules, and since you only need to consume one per day, this bottle will last you two whole months, great for getting healthy on a budget.

Naturelo probiotics are also ideal for people with food sensitivities like soy, gluten, dairy, sugar, eggs, nuts, and preservatives that can cause the small intestines to flare up, as this probiotic contains none of those potentially-harmful ingredients. 


4. Earth’s Pearl Probiotic + Prebiotic Supplement


  • Weight – 1.45 ounces
  • Size – 3.5 x 1.7 x 1.7 inches
  • Qty pack – 60
  • Item form – Pearl pills
  • Sensitivities – Yeast-free, gluten-free, lactose-free, soy-free, egg-free, shellfish-free, nut-free, artificial ingredient-free, vegan
  • CFUs – 4 billion 
  • Strains – 4
  • Function – Eases digestive distress, boosts immune system, prevents yeast growth, boosts energy
  • Dosage – 1-3 pearls per day
  • Pearl pills are easier to swallow than capsules
  • Pearl pills have a longer shelf life
  • Ideal for those with food sensitivities or allergies
  • Offers 4 billion CFUs per pearl
  • 4 strains per pearl
  • Eases digestive distress
  • Boosts your immune system
  • Prevents yeast growth and increases energy
  • An Amazon’s Choice product
  • Other probiotics offer more CFUs and strains per capsule
  • May have to consume up to 3 per day for effective results


This is another good probiotic supplement for those who don’t have extreme tummy troubles, but want to boost their immune system, prevent yeast growth, and enhance their energy and mood.

These probiotics are a little different since they come in the form of tiny pearls that are super easy to swallow. This is an ideal product for those who have a tough time getting large capsules down. The pearls offer you 4 billion CFUs and 4 strains with every pearl you take.

One bottle includes 60 pearls, which should be enough to last you a whole month since you only need to consume 1-3 per day for effective relief.

The product is ideal for those with lots of food sensitivities and allergies because it’s free from gluten, yeast, lactose, soy, eggs, shellfish, nuts, and other artificial ingredients. 


5. BioSchwartz Extra Strength Probiotic with 65 Billion CFUs


  • Weight – 2.08 ounces
  • Size – 4.49 x 2.32 x 2.28 inches
  • Qty pack – 30 or 60
  • Item form – Capsules
  • Sensitivities – Gluten-free, filler-free, GMO-free, vegan
  • CFU’s – 65 billion
  • Strains – 13
  • Dosage – 1 capsule per day
  • Function – Supports digestive health, boosts immune system, promotes regularity, supports whole body health

  • Comes in 30 or 60-capsule bottles
  • 65 billion CFUs per capsule
  • 13 strains per capsule
  • Ideal for those with gluten sensitivities
  • Supports digestive health
  • Boosts your immune system
  • Promotes regularity and a healthy weight
  • Only one capsule needed per day
  • #1 best seller
  • Might not be suitable for those with nut and egg allergies
  • Might not be suitable for those with milder digestive issues


This is the most powerful probiotic on our list. It’s an ideal product for those with severe regularity issues and can boost your overall digestive health and immune system function.

Each capsule offers you 65 billion CFUs and 13 probiotic strains to help restore balance to your gut and improve food digestion. This product is available in 30 or 60-capsule packs, but because you only need to consume 1 per day, one bottle will be enough for a whole month.

These BioSchwartz probiotics are ideal for those with gluten, filler, and GMO sensitivities, but it might not be the best probiotic supplement to take if you have other food sensitivities, as it’s unclear whether this product is free from traces of egg, nuts, soy, and other common allergens.


Our Top Picked Product

Top Product

Probiotics 60 Billion CFU

Probiotics and Organic Prebiotics: Our Doctor-Approved probiotics are made with prebiotics and probiotics based on clinical research. A complete probiotic supplement for ultimate digestive health.

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